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| Substance Identification: |
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| 1H-Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl- |
| CAS Number: 58-08-2 |
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| Names and Synonyms: |
| 1,3,7-Trimethyl-2,6-dioxo-1,2,3,6-tetrahydropurine |
| 1,3,7-Trimethyl-2,6-dioxopurine |
| 1,3,7-Trimethyl-3,7-dihydro-1H-purin-2,6-dion |
| 1,3,7-Trimethyl-3,7-dihydro-1H-purine-2,6-dione |
| 1,3,7-Trimethylxanthine |
| 1-Methyl-Theobromine |
| 1-Methyltheobromine |
| 1H-Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl- |
| 3,7-Dihydro-1,3,7-trimethyl-1H-purin-2,6-dion (coffein) |
| 3,7-Dihydro-1,3,7-trimethyl-1H-purine |
| 3,7-Dihydro-1,3,7-trimethyl-1H-purine (9CI) |
| 3,7-Dihydro-1,3,7-trimethyl-1H-purine-2, 6-dione |
| 3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione |
| 7-Methyl Theophylline |
| 7-Methyltheophylline |
| Alert-pep |
| Anhydrous caffeine |
| Anhydrous caffeine (JP15) |
| BRN 0017705 |
| Cafamil |
| Cafecon |
| Cafeina |
| Caffedrine |
| Caffein |
| Caffeine |
| Caffeine, anhydrous |
| Caffeine, synthetic |
| Caffenium |
| Caffine |
| Cafipel |
| CCRIS 1314 |
| Coffeine |
| Coffeinum |
| Dexitac |
| Eldiatric C |
| Guaranine |
| Hycomine |
| Methyltheobromine |
| Methylxanthine theophylline |
| Nix Nap |
| NO-Doz |
| Nodaca |
| NSC 5036 |
| Organex |
| Quick-Pep |
| Refresh'N |
| Shape Plus |
| Stim |
| Thein |
| Theine |
| Theobromine, 1-methyl- |
| Theophylline, 7-methyl |
| Tirend |
| Tri-Aqua |
| Vivarin |
| Wigraine |
| Xanthine, 1,3,7-trimethyl |
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| Български (bg): |
| Кафеин (или кофеин) |
| Deutsch (de): |
| 1,3,7-Trimethylxanthin |
| Coffein |
| Guaranin |
| Koffein |
| Methyltheobromin |
| Teein |
| Thein |
| Español (es): |
| Cafeina |
| Français (fr): |
| Caféine |
| Guaranine |
| Méthylthéobromine |
| Méthylthéophylline |
| Matéine |
| Théine |
| 日本語 (ja): |
| カフェイン |
| メチルテオフィリン |
| メチルテオブロミン |
| 1,3,7-トリメチルキサンチン |
| Italiano (it): |
| Caffeina |
| Nederlands (nl): |
| Cafeïne |
| Mateïne |
| Theïne |
| 中文 (zh): |
| 咖啡因 |
| 咖啡因 (精神类不能定购) |
| 无水咖啡因 |
| 无水咖啡碱 |
| 茶素 |
| 1,3,7-三甲基黄嘌呤 |
| 1,3,7-三甲基-3,7-二氢-1H-嘌呤-2,6-二酮 |
| 3,7-二氢-1,3,7-三甲基-1H-嘌呤-2,6-二酮 |
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| IUPAC Name: |
| 1,3,7-trimethylpurine-2,6-dione |
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| InChI: |
| InChI=1/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 |
| Smiles: |
| c12c(n(c(=O)n(c1=O)C)C)ncn2C |
| Molecular Formula: |
| C8H10N4O2 |
| Inventories: |
| DSL - EINECS - NZIoC - TSCA |
| Other Lists: |
| CCRIS - ChemBlink - CPDB - ECHA Pre-Registred Substances - EPA HPV - EU HPV - HSDB - HSNO CCID - IARC - SPIN |
| Comment: |
Group 3: Not classifiable as to carcinogenicity to humans.
IARC (International Agency for Research on Cancer).
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A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent.
Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation.
It also relaxes smooth muscle, stimulates cardiac muscle, stimulates diuresis, and appears to be useful in the treatment of some types of headache.
Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile.
Among the most important are inhibition of cyclic nucleotide phosphodiesterases, antagonism of adenosine receptors, and modulation of intracellular calcium handling.
MeSH (Medical Subject Headings File).
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Domestic Substances List (DSL) and Non-Domestic Substances List (NDSL):
EPA's Toxic Substances Control Act Chemical Substance Inventory (TSCA):
EPA Substance Registry Services (EPA SRS):
EPA High Production Volume (HPV) Challenge Program:
EPA High Production Volume Information System (HPVIS):
| EPA HPVIS, no records were found for this chemical substance. |
EPA Toxics Release Inventory (TRI) Program:
| TRI, no records were found for this chemical substance. |
Carcinogenic Potency Database (CPDB):
Chemical Carcinogenesis Research Information System (CCRIS):
Hazardous Substances Data Bank (HSDB):
Medical Subject Headings (MeSH):
Toxicology Literature Online (TOXLINE):
European INventory of Existing Commercial chemical Substances (EINECS):
| Chemical Name | : | Caffeine |
| EC Number | : | 200-362-1 |
Classification and Labelling for substances placed on Annex I of Directive 67/548/EEC:
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| Classification |
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Xn; R22 |
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| Risk Phrase |
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R22 : Harmful if swallowed. Hide ML
| Български (bg) | Вреден при поглъщане. |
| Čeština (cs) | Zdraví škodlivý při požití. |
| Dansk (da) | Farlig ved indtagelse. |
| Deutsch (de) | Gesundheitsschädlich beim Verschlucken. |
| Ελληνικό (el) | Επιβλαβές σε περίπτωση καταπόσεως. |
| Español (es) | Nocivo por ingestión. |
| Eesti keel (et) | Kahjulik allaneelamisel. |
| Suomi (fi) | Terveydelle haitallista nieltynä. |
| Français (fr) | Nocif en cas d'ingestion. |
| Magyar (hu) | Lenyelve ártalmas. |
| Italiano (it) | Nocivo per ingestione. |
| 日本語 (ja) | 飲み下すと有害性がある. |
| Lietuvių kalba (lt) | Kenksminga prarijus. |
| Latviešu valoda (lv) | Kaitīgs norijot. |
| Malti (mt) | Jagħmel ħsara meta jinbela'. |
| Nederlands (nl) | Schadelijk bij opname door de mond. |
| Polski (pl) | Dziala szkodliwie po polknieciu. |
| Português (pt) | Nocivo por ingestão. |
| Slovenčina (sk) | Škodlivý po požití. |
| Slovenščina (sl) | Zdravju škodljivo pri zaužitju. |
| Svenska (sv) | Farligt vid förtäring. |
| 中文 (zh) | 吞食有害. |
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| Safety Phrases |
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S2 : Keep out of the reach of children. Hide ML
| Български (bg) | Да се пази от достъп на деца. |
| Čeština (cs) | Uchovávejte mimo dosah dětí. |
| Dansk (da) | Opbevares utilgængeligt for børn. |
| Deutsch (de) | Darf nicht in die Hände von Kindern gelangen. |
| Ελληνικό (el) | Μακριά από παιδιά. |
| Español (es) | Manténgase fuera del alcance de los niños. |
| Eesti keel (et) | Hoida lastele kättesaamatus kohas. |
| Suomi (fi) | Säilytettävä lasten ulottumattomissa. |
| Français (fr) | Conserver hors de la portee des enfants. |
| Magyar (hu) | Gyermekek kezébe nem kerülhet. |
| Italiano (it) | Conservare fuori della portata dei bambini. |
| 日本語 (ja) | 子供の手の届かない場所に保管する. |
| Lietuvių kalba (lt) | Saugoti nuo vaikų. |
| Latviešu valoda (lv) | Sargāt no bērniem. |
| Malti (mt) | Żomm fejn ma jintlaħaqx mit-tfal. |
| Nederlands (nl) | Buiten bereik van kinderen bewaren. |
| Polski (pl) | Chronic przed dziecmi. |
| Português (pt) | Manter fora do alcance das crianças. |
| Slovenčina (sk) | Uchovávajte mimo dosahu detí. |
| Slovenščina (sl) | Hraniti izven dosega otrok. |
| Svenska (sv) | Förvaras oåtkomligt för barn. |
| 中文 (zh) | 防止儿童触及. |
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Danger / Hazards
Indication(s) and Symbol(s) |
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Xn : Harmful Hide ML
| Български (bg) | Вредно |
| Čeština (cs) | Zdraví škodlivý |
| Dansk (da) | Sundhedsskadelig |
| Deutsch (de) | Gesundheitsschädlich |
| Ελληνικό (el) | Επιβλαβές |
| Español (es) | Nocivo |
| Eesti keel (et) | Kahjulik |
| Suomi (fi) | Haitallinen |
| Français (fr) | Nocif |
| Magyar (hu) | Ártalmas |
| Italiano (it) | Nocivo |
| 日本語 (ja) | 有害 |
| Lietuvių kalba (lt) | Kenksminga |
| Latviešu valoda (lv) | Kaitīgs |
| Malti (mt) | Jagħmel il-ħsara |
| Nederlands (nl) | Schadelijk |
| Norsk (no) | Helseskadelig |
| Polski (pl) | Produkt szkodliwy |
| Português (pt) | Nocivo |
| Slovenčina (sk) | Škodlivý |
| Slovenščina (sl) | Zdravju škodljivo |
| Svenska (sv) | Hälsoskadlig |
| 中文 (zh) | 和有害物质 |
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EU High and Low Production Volume Chemicals (EU HPV-LPV):
ECHA List of Pre-Registered Substances:
| The REACH Regulation requires that ECHA will publish by 1 January 2009 a list of substances which have been pre-registered between 1 June and 1 December 2008. |
Substances in Preparations in Nordic Countries (SPIN):
Online Informational Database of Chemicals from China (ChemBlink):
Australian High Volume Industrial Chemicals List (HVICL):
| NICNAS HVICL, no records were found for this chemical substance. |
ERMA New Zealand Inventory of Chemicals (NZIoC):
HSNO Chemical Classification Information Database (CCID):
International Agency for Research on Cancer (IARC):
| Chemical Name | : | Caffeine |
| Volume, Date | : | Vol. 51; 1991 |
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Provides information on chemical substances like:
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- Formaldehyde, caffeine, phthalates.
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